Journal Reviews

Selective denervation of the bladder

1 March 2019 | | denervation, overactive bladder, tissue ablation, tissue healing, ablation, afferent nerves, fulguration, micturition, minimally invasive, radiofrequency, trigone

The treatment of refractory overactive bladder is currently limited to neuromodulation (sacral nerve stimulation or percutaneous tibial nerve stimulation) or botulinum toxin injections. Although all these options are valuable, they have their own limitations and may not be suitable for...

Oestrogens and OAB

1 January 2015 | | Functional Urology | hormone replacement therapy, oestrogen, overactive bladder

This is a multicentre study from Europe. The female genitals and lower urinary tract have a common embryological origin arising from urogenital sinus. Therefore, both could be sensitive to female sex steroid hormones. Oestrogens and progesterone receptors have been demonstrated...

Beta 3 receptors in OAB

1 November 2014 | | Urologic Oncology | beta3-adrenoceptor, overactive bladder, polymorphism

More and more is written on Beta 3 receptors in human bladders and their role in detrusor relaxation. This study from Japan investigated human Beta 3 AR gene which is polymorphic. One hundred women with overactive bladder (OAB) and 101...

New therapy for overactive bladder

1 July 2014 | | Functional Urology | Mirabegron, overactive bladder, β3-adrenoceptor agonist

Overactive bladder (OAB) is a complex symptom that can adversely affect quality of life. So far pharmacotherapy has focused on anti-cholinergic drugs. Recently, beta-adrenoreceptors have been identified as having an effect on the detrusor muscle and urothelium. Beta-3 is the...